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Hashimoto, Kazuyuki; Wan, K. W. H. B. B.*; Matsuoka, Hiromitsu
Journal of Nuclear and Radiochemical Sciences, 6(3), p.193 - 196, 2005/12
The radioisotopes of rhenium (Re and Re) are attractive radionuclides for radiotherapy because of their energetic beta particles and gamma rays suitable for imaging. Mercaptoacetyltriglycine, MAG3 (NS ligand), is a useful bifunctional ligand in labeling monoclonal antibodies with metallic radionuclides. In this study, the labeling of MAG3 with carrier-free Re from a W/Re generator was investigated in detail. The Re-MAG3 complex was synthesized by the direct labeling method and by the indirect labeling method using a transfer ligand (citric acid or gluconic acid). The dependence of the labeling yield upon the reaction conditions such as the concentrations of tin(II) chloride dihydrate as a reducing agent, S-benzoyl MAG3 and the transfer ligand, pH, temperature, reaction time and the addition of a carrier was examined. The labeling yield of Re-MAG3 synthesized by the all method was over 90% under the optimum conditions.
Uehara, Tomoya*; Koike, Miho*; Nakata, Hideo*; Miyamoto, Shigehiko*; Motoishi, Shoji; Hashimoto, Kazuyuki; Oku, Naoto*; Nakayama, Morio*; Arano, Yasushi*
Nuclear Medicine and Biology, 30(3), p.327 - 334, 2003/04
Times Cited Count:20 Percentile:50.08(Radiology, Nuclear Medicine & Medical Imaging)no abstracts in English
Kobayashi, Katsutoshi; Motoishi, Shoji; Terunuma, Kuzuo; Rauf, A. A.*; Hashimoto, Kazuyuki
Radiochemistry, 42(6), p.551 - 554, 2000/12
no abstracts in English
Ogawa, Kazuma*; Ono, Masahiro*; Fujioka, Yasushi*; Saji, Hideo*; Mukai, Takahiro*; Konishi, Junji*; Uehara, Tomoya*; Arano, Yasushi*; Onoma, Katsuyuki
Kaku Igaku, 37(5), P. 577, 2000/09
no abstracts in English
*; *; *; *; *; Hashimoto, Kazuyuki; *
Journal of Radioanalytical and Nuclear Chemistry, 239(2), p.385 - 389, 1999/00
Times Cited Count:2 Percentile:21.16(Chemistry, Analytical)no abstracts in English
Hashimoto, Kazuyuki; *
Top. Curr. Chem., 176, p.276 - 291, 1996/00
no abstracts in English